![]() ![]() Hamilton E, Pattrick M, Hornby J, Derrick G, Doherty M.Supravital staining of synovial fluid with Testsimplets. Reginato AJ, Maldonado I, Reginato AM, Falasca GF, O'Connor CR.Detection of crystals in synovial fluids by light microscopy: sensitivity and reliability. Reproducibility of synovial fluid analyses. Schumacher HR, Jr, Sieck MS, Rothfuss S, Clayburne GM, Baumgarten DF, Mochan BS, Kant JA.Variation in synovial fluid analysis by hospital laboratories. Analysis for crystals in synovial fluid: training of the analysts results in high consistency. Lumbreras B, Pascual E, Frasquet J, González-Salinas J, Rodríguez E, Hernández-Aguado I.Most calcium pyrophosphate crystals appear as non-birefringent. Treatment with colchicine decreases white cell counts in synovial fluid of asymptomatic knees that contain monosodium urate crystals. Persistence of monosodium urate crystals and low-grade inflammation in the synovial fluid of patients with untreated gout. A quantitative study of the phagocytosis of urate crystals in the synovial fluid of asymptomatic joints of patients with gout. Can we determine when urate stores are depleted enough to prevent attacks of gout? J Rheumatol. Li-Yu J, Clayburne G, Sieck M, Beutler A, Rull M, Eisner E, Schumacher HR., Jr Treatment of chronic gout.Synovial fluid analysis for diagnosis of intercritical gout. Pascual E, Batlle-Gualda E, Martínez A, Rosas J, Vela P.Monosodium urate, hydroxyapatite, and calcium pyrophosphate crystals induce tumor necrosis factor-alpha expression in a mononuclear cell line. Meng ZH, Hudson AP, Schumacher HR, Jr, Baker JF, Baker DG.Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. ![]() Crystal-neutrophil interactions lead to interleukin-1 synthesis. Roberge CJ, Grassi J, De Médicis R, Frobert Y, Lussier A, Naccache PH, Poubelle PE.Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation. Terkeltaub R, Zachariae C, Santoro D, Martin J, Peveri P, Matsushima K.Inflammatory microcrystals stimulate interleukin-6 production and secretion by human monocytes and synoviocytes. Guerne PA, Terkeltaub R, Zuraw B, Lotz M.Crystal-induced inflammation of the joints. An experimental model with quantification of the host response. Crystal-induced inflammation in canine joints. Calcium pyrophosphate dihydrate crystal deposition disease-1975. The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: the "pseudogout syndrome". KOHN NN, HUGHES RE, McCARTY DJ, Jr, FAIRES JS.This may not be the complete list of references from this article. The Full Text of this article is available as a PDF (78K). The raised cell counts and percentage of PMN suggest mild subclinical inflammation in these joints. Most of the intracellular crystals were inside mononuclear cells (22.2% of all the cells (95% CI, CI 18.5% to 25.9%)), although some PMN also contained them (1.8% of all the cells (95% CI, 1.1% to 2.4%)).Ĭonclusions: CPPD crystals are normally found in synovial fluid of non-inflamed joints of patients with CPPD related arthropathy, and they interact with cells. All the samples contained intracellular CPPD crystals, which were found in 24.0% of all the cells (95% CI, 20.1% to 27.9% range 1% to 78%). Results: All 74 samples contained CPPD crystals. A supravital stain (Testsimplets, Boehringer Mannheim) was used to carry out differential counts and to assess the presence of intracellular crystals. Identification of CPPD crystals and synovial fluid cell counts were done manually in undiluted samples using a haematocytometric chamber. Methods: 74 synovial fluid samples were obtained from non-inflamed knees of 74 patients with CPPD related arthropathy. ![]() Objectives: To determine whether calcium pyrophosphate dihydrate (CPPD) crystals can be found in the synovial fluid of non-inflamed joints in patients with CPPD related arthropathy if so, to determine whether they interact with cells and produce subclinical inflammation in this setting. ![]()
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